Acute experimental pulmonary responses to cardroom cotton dust.
Kutz-SA; Mentnech-MS; Mull-JC; Olenchock-SA; Major-PC
Arch Environ Health 1980 Sep; 35(4):205-210
The effect of cotton dust on pulmonary response was tested in female New-Zealand-White-rabbits. Baseline resting blood gas levels for each animal were determined. The animals were exposed to untreated cardroom cotton dust (BCD) aerosols for 1 hour per day, 4 days per week for 15 consecutive weeks. During the exposures, 500 milligrams of dust were added every 10 minutes at an air flow rate of 35 liters per minute. One week after the end of the BCD studies, four rabbits which had reacted to the BCD were subjected to a similar challenge with washed and lyophilized cotton dust (TCD). Both TCD and BCD were of similar particle size. At 1 hour post-exposure, significant decreases in arterial oxygen tension (PaO2) occurred which became progressively greater throughout the study. Increases in arterial carbon-dioxide (124389) tension (PaC02) were observed. The alveolar- arterial oxygen gradient (A-a) increased as the exposure regimen continued. No significant changes in Pa02, PaC02 or A-a were noted at 3 hours post-exposure, while at 5 and 24 hours significant decreases in PaO2 were seen. In rabbits exposed to TCD, the mean decrease of PaO2 at 1 hour post-exposure was about five times less than the mean decrease at 15 weeks of exposure to BCD. The 1 hour post-exposure A-a for the BCD exposure was three times greater than after TCD exposure. The authors conclude that BCD is a much more potent incident of respiratory pathophysiology than TCD.
NIOSH-Author; Epidemiology; Cotton-dusts; Airborne-dusts; Air-contamination; Pulmonary-system-disorders; Workplace-studies; Laboratory-animals; Particulates; Blood-analysis
Archives of Environmental Health