Effect of acrylamide intoxication on pyridine nucleotide concentrations and functions in rat cerebral cortex.
Biochem Pharmacol 1977; 26(22):2151-2155
The effect of acrylamide (79061) on pyridine nucleotide concentrations was studied in male Holtzman-rats. Animals were administered 40 milligrams per kilogram (mg/kg) per week of acrylamide and were sacrificed when the total cumulative dose was 428 or 668mg/kg. Rats given the lower cumulative dose developed mild symptoms of intoxication characterized by decreased body tone and increased excitability. Animals receiving the higher dose were more severely affected. While nicotinamide-adenine-dinucleotide- phosphate concentrations remained constant, nicotinamide-adenine- dinucleotide (NAD) concentrations showed a dose-related increase in the treated rats. NAD concentrations were significantly higher than controls in the high dose animals. Of the substrates, only the increase in alpha-glycerophosphate in the high dose rats was significant. There were no significant differences between control and treated rats for any high-energy phosphate source. The authors suggest that lipid metabolism may be affected in acrylamide intoxication.
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