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Effect of acrylamide intoxication on pyridine nucleotide concentrations and functions in rat cerebral cortex.
Johnson EC; Murphy SD
Biochem Pharmacol 1977; 26(22):2151-2155
The effect of acrylamide (79061) on pyridine nucleotide concentrations was studied in male Holtzman-rats. Animals were administered 40 milligrams per kilogram (mg/kg) per week of acrylamide and were sacrificed when the total cumulative dose was 428 or 668mg/kg. Rats given the lower cumulative dose developed mild symptoms of intoxication characterized by decreased body tone and increased excitability. Animals receiving the higher dose were more severely affected. While nicotinamide-adenine-dinucleotide- phosphate concentrations remained constant, nicotinamide-adenine- dinucleotide (NAD) concentrations showed a dose-related increase in the treated rats. NAD concentrations were significantly higher than controls in the high dose animals. Of the substrates, only the increase in alpha-glycerophosphate in the high dose rats was significant. There were no significant differences between control and treated rats for any high-energy phosphate source. The authors suggest that lipid metabolism may be affected in acrylamide intoxication.
NIOSH-Publication; NIOSH-Grant; Grants-other; Biochemistry; Physiology; Dose-response; Toxicology; Laboratory-animals; Metabolism
Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
Issue of Publication
Other Occupational Concerns; Grants-other
Harvard University, Boston, Massachusetts
Page last reviewed: February 4, 2022
Content source: National Institute for Occupational Safety and Health Education and Information Division