Proceedings of A Workshop/Conference on the Role of Metals in Carcinogenesis, Atlanta, Georgia, March 24-28, 1980.
The proceedings of a workshop and conference on the role of metals in carcinogenesis is reviewed. Participants are listed from 11 countries. Recommendations are formulated for future research on the carcinogenicity of arsenic (7440382), nickel (7440020) and other metals. The workshop reports consist of general findings and recommendations, problems of epidemiological evidence, experimental studies in whole animal bioassay, chemistry and metabolism of metals relevant to their carcinogenicity, and in-vitro models and methods for bioassay and studies of cellular mechanisms. Commissioned papers are presented for sources, transport, and alterations of metal compounds; metal interactions in carcinogenesis; whole animal bioassay; cadmium induced prostate cancer; chromosome aberrations; relationships between metal toxicity and subcellular systems; mutagenicity and DNA repair; infidelity of DNA synthesis; chemistry of carcinogenic metals; chelating agents; and biochemistry and metabolism of carcinogenic metals. Conclusions developed from the conference indicate that there is sufficient evidence that some of these metals contribute to the development of cancer in man and that monitoring programs are needed to assess human exposure, along with assessments of concomitant exposures to other carcinogenic or cocarcinogenic substances. Recommendations are given for monitoring programs and exposure assessment, analytical models, identification of factors determining susceptibility, biological measurement of metal concentrations, and quantitative systematic investigations of routes of metal intake.