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Respiratory and Immunologic Evaluation of Isocyanate Exposure in a New Manufacturing Plant.
National Institute for Occupational Safety and Health 1977:84 pages
Respiratory and immunological reactivity to isocyanates was studied among 160 workers exposed to toluene-diisocyanate (26471625) (TDI) at a manufacturing facility in Louisiana. The workers were tested periodically between 1973 and 1976. TDI exposure was determined based on job assignment. Pulmonary function and skin tests were conducted, and the workers completed respiratory symptom questionnaires. Among TDI exposed subjects, there was a significant excess of bronchitis and upper and lower respiratory symptoms. Results of the pulmonary function tests did not differ between exposure groups. Six of 17 former workers had mild to moderate obstructive respiratory impairment. Positive immunological reactions were found in an unspecified number of workers. Environmental testing data indicated average personal TDI exposures ranging from 0.002 to 0.007 parts per million. Exposures to chlorine gas and phosgene vapor also were noted. The authors note that testing at this facility will continue in order to correlate TDI exposure with symptom prevalence and severity and to monitor longitudinal changes in respiratory function.
NIOSH-Contract; Contract-210-75-0006; Pulmonary-system-disorders; Immune-reaction; Cyanates; Industrial-factory-workers; Occupational-exposure; Work-operations; Skin-tests; Air-contamination;
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Pulmonary-system-disorders;
National Institute for Occupational Safety and Health
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division