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Criteria for a recommended standard: occupational exposure to diisocyanates.
Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-215, 1978 Sep; :1-138
Information on the toxicity and recommended exposure standards of diisocyanates is presented. Production methods and industrial uses of the chemicals are reviewed. Effects of exposure on the respiratory, immunologic and dermatologic systems in humans are discussed, along with the results of various epidemiologic and laboratory animal studies. Environmental concentrations of diisocyanates are noted, and current methods of engineering controls and sampling and analysis are described. The authors recommend that diisocyanate exposures be kept to 5 parts per billion (ppb) for a 10 hour time weighted average and 20ppb for a 10 minute ceiling exposure. Recommendations are included for medical monitoring, product labeling, use of personal protective clothing and equipment, worker hazard education, work practices, workplace hygiene, workplace monitoring, and recordkeeping procedures.
Toxic-effects; Worker-health; Work-operations; Occupational-exposure; Pulmonary-system; Immune-system; Dermatology; Environmental-engineering; NIOSH-Criteria-Document
Numbered Publication; Criteria Document
NTIS Accession No.
DHEW (NIOSH) Publication No. 78-215; Contract-210-77-0015
National Institute for Occupational Safety and Health
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division