Criteria for a recommended standard... occupational exposure to 1,1,1- trichloroethane (methyl chloroform).
Information on the toxicity and recommended exposure standards for 1,1,1-trichloroethane (71556) is presented. Chemical properties of the compound are reviewed, along with industrial production figures, uses, and worker exposures. Results of epidemiological and animal toxicity studies are discussed. Toxic effects on the human nervous and cardiovascular systems are described, along with case reports of intentional, accidental and suicidal exposures. Guidelines are included for occupational and environmental 1,1,1-trichloroethane exposures, medical surveillance procedures, labeling of products, and use of protective clothing and equipment. Sampling and analytical procedures are discussed, together with engineering control methods. The author recommends a 350 parts per million (ppm) ceiling limit for 1,1,1-trichloroethane, and a 200ppm action concentration. Recommendations are included for transport, handling and use of the chemical, equipment maintenance, emergency management, use of respiratory protection, sampling procedures, and medical monitoring programs. Further research is suggested on epidemiology, chronic toxicity, genetic effects, and synergistic effects with hydrocarbons and organic solvents.