Effect of ozone on elastic behavior of excised lungs of dogs.
Frank-R; Flesch-JP; Brain-JD
Environ Res 1971 Oct; 4(4):343-354
The effects of ozone (10028156) on lung elasticity were studied in mongrel dogs. Paired lung lobes were excised. One lobe was ventilated with filtered air for 3 hours, and the other was ventilated with filtered air for 30 minutes followed by ozone for 2.5 hours. A slight depression of the static volume pressure (P/V) relationship occurred in lobes exposed to 6.8 to 10.3 parts per million of ozone for 2.5 hours. Dynamic compliance decreased more rapidly in lobes ventilated with ozone. The authors note that depressed P/V occurred at ozone concentrations great enough to cause pulmonary edema and death in vivo. They conclude that ozone causes limited changes in the elastic behavior of excised lobes. They suggest that the primary cause of altered elastic behavior during short term exposure to ozone in vivo may be the occurrence of edema, severe changes in airway flow resistance, or shifts in lung volume.
NIOSH-Publication; NIOSH-Grant; Toxic-effects; Oxidizers; Respiratory-irritants; Lung-function; Laboratory-animals; Pulmonary-system-disorders; Pulmonary-function; Elastic-properties
Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
University of Washington, Seattle, Washington