Interactions of sulfur dioxide and acrolein as sensory irritants.
Toxicol Appl Pharmacol 1979 Apr; 48(2):305-315
The effects of sulfur-dioxide (7446095) (SO2) and acrolein (107028) on respiration were evaluated in mice. Swiss-Webster-mice were exposed to 3.4, 1.27 or 0.85 parts per million (ppm) acrolein, 9 to 140ppm SO2, or to a combination of the two in the same individual concentrations. The irritants were introduced into the chamber for 10 minute periods, rates were recorded immediately after the animals breathed room air. The pattern of respiratory response was correlated with the concentration of the irritant. At high SO2 concentrations the response was typical of SO2 and the acrolein effect was blocked. An acrolein type response was observed at high acrolein concentrations. Post exposure recovery after exposure to both irritants was slower than with each irritant alone. The authors conclude that SO2 and acrolein have a ratio dependent antagonistic effect and combined exposure causes a prolongation of irritation after exposure is terminated.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Biochemistry; Chemical-analysis; Physiology; Dose-response; Toxicology; Chemical-properties; Laboratory-animals
Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
Toxicology and Applied Pharmacology
University of Pittsburgh, Pittsburgh, Pennsylvania