Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor.
Infante-PF; Epstein-SS; Newton-WA
Scand J Work, Environ & Health 1978 Jun; 4(2):137-150
Five case reports of neuroblastomas in children, and three cases each of acute leukemia and aplastic anemia associated with exposure to chlordane (57749) are reviewed. Prior literature is reviewed and 25 cases of blood dyscrasia associated with chlordane or heptachlor (76448) are cited. The environmental distribution of chlordane and heptachlor and their appearance in the food chain are reviewed. The authors note that attempts to survey pesticide workers have met with little success because of poor response rates and high turnover in the industry. Because of the environmental accumulation of the agents, humans may be exposed from conception throughout adult life. The authors recommend epidemiologic studies to evaluate health risks associated with both home and occupational uses of chlordane and heptachlor.
NIOSH-Author; Biochemistry; Physiology; Toxicology; Chemical-properties; Cancer; Carcinogens;
Author Keywords: acute; leukemia; aplastic anemia; Chlordane; neuroblastoma
Dr. P. F. Infante, Office of Carcinogen Identification and Classification, Occupational Safety and Health Administration, U.S. Department of Labor, 3rd and Constitution Avenue, N.W., Washington, D.C. 20210, U.S.A.
Scandinavian Journal of Work, Environment and Health