NIOSHTIC-2 Publications Search

Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor.

Authors
Infante PF; Epstein SS; Newton WA
Source
Scand J Work Environ Health 1978 Jun; 4(2):137-150
NIOSHTIC No.
00107209
Abstract
Five case reports of neuroblastomas in children, and three cases each of acute leukemia and aplastic anemia associated with exposure to chlordane (57749) are reviewed. Prior literature is reviewed and 25 cases of blood dyscrasia associated with chlordane or heptachlor (76448) are cited. The environmental distribution of chlordane and heptachlor and their appearance in the food chain are reviewed. The authors note that attempts to survey pesticide workers have met with little success because of poor response rates and high turnover in the industry. Because of the environmental accumulation of the agents, humans may be exposed from conception throughout adult life. The authors recommend epidemiologic studies to evaluate health risks associated with both home and occupational uses of chlordane and heptachlor.
Keywords
NIOSH-Author; Biochemistry; Physiology; Toxicology; Chemical-properties; Cancer; Carcinogens; Author Keywords: acute; leukemia; aplastic anemia; Chlordane; neuroblastoma
Contact
Dr. P. F. Infante, Office of Carcinogen Identification and Classification, Occupational Safety and Health Administration, U.S. Department of Labor, 3rd and Constitution Avenue, N.W., Washington, D.C. 20210, U.S.A.
CODEN
SWEHDO
CAS No.
57-74-9; 76-44-8
Publication Date
19780601
Document Type
Journal Article
Fiscal Year
1978
Issue of Publication
2
ISSN
0355-3140
Source Name
Scandinavian Journal of Work, Environment & Health
State
DC; IL; OH
Page last reviewed: June 28, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division