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Methyl-n-butyl ketone and peripheral neuropathy.
Mallov JS; Marceleno T; Fontaine R
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, IWS 47-3, 1975 Jun; :1-23
The neurotoxicity of methyl-butyl-ketone (591786) (MBK) is discussed. Animal toxicity studies and five case reports of peripheral neuropathy in exposed workers are reviewed. Results of neurologic examinations of 207 workers from four paint manufacturing companies (SIC-2851) are evaluated. The authors conclude that MBK can cause peripheral neuropathy in humans, even at concentrations as low as 100 parts per million. Proper engineering controls can reduce the hazards of exposure to MBK.
NIOSH-Author; NIOSH-Survey; Field-Study; Region-5; Pesticides-and-agricultural-chemicals; Health-surveys; Workplace-studies; Air-contamination; Occupational-health-programs; Case-studies
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National Institute for Occupational Safety and Health
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