Respiratory and Immunologic Evaluation of Isocyanate Exposure in a New Manufacturing Plant.
NIOSH 1979 Sep:101 pages
The effects of isocyanate (71000823) exposure on respiration and immunology were studied in workers at a toluene-diisocyanate (584849) (TDI) manufacturing facility (SIC-5161) in Louisiana. In April 1973 before TDI production began, 168 workers were given a medical questionnaire to compile smoking histories and to determine the presence of upper and lower respiratory symptoms and bronchitis. Spirometric tests were administered to determine lung volume and diffusing capacities. Follow up visits and tests continued periodically for over 5 years; the last one was made in October 1978. Eight-hour time weighted averages for TDI exposure of 1949 personal samples respiratory 42 jobs titles were obtained. TDI developed in 4.3 percent of the study population. The values of the parameters of lung function declined, and some of the workers in the study group had evidence of sensitization to TDI.
NIOSH-Contract; Contract-210-75-0006; Cyanates; Occupational-exposure; Pulmonary-system-disorders; Hypersensitivity;
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Pulmonary-system-disorders;
Tulane University School of Medicine, New Orleans, Louisiana, NIOSH Contract No. 210-75-0006, 101 pages