Epidemiological Studies for Detection of Teratogens.
NIOSH 1980 Oct:357-376
Epidemiological methods of detecting teratogenic agents are reviewed. Population, cohort and case control study procedures are evaluated based on data collected during previous investigations. Confounding factors in each type of study are discussed, including secondary or unknown exposures, subject selection, chance correlations, and maternal memory bias. The author concludes that epidemiological studies can identify teratogenic agents or populations at risk. For teratology studies involving industrial chemical exposures, retrospective or prospective cohort studies would provide the most meaningful data.
Epidemiology; Teratogenesis; Case-studies; Risk-factors; Industrial-chemicals;
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services