Monitoring Y Chromosomal Nondisjunction in Humans with the YFF Sperm Tests.
Kapp-RW; Benge-MC; Picciano-DJ; Kilian-DJ; Legator-MS; Jacobson-CB
NIOSH 1980 Oct:307-325
Y-Chromosomal nondisjunction in humans was evaluated based on YFF frequency in sperm. Semen samples from healthy males, tumor patients who received radiation therapy, and workers exposed to dibromochloropropane (96128) (DBCP) were examined for YFF frequency by two independent scores. Among healthy males, the average incidence of single and double F-body sperm was 41.4 and 1.1 percent, respectively. The frequence of double F-body sperm was significantly increased in the tumor patients and the DBCP exposed workers. In all cases, values provided by the two scores were in dose agreement. The authors conclude that YFF analysis can be used to detect Y-chromosomal nondisjunction, and can be used to monitor exposures of human males to mutagenic agents. They recommend that men with histories of chemotherapy radiation or industrial chemical exposure, undergo YFF evaluation prior to attempting conception. Genetic counseling and amniocentesis should be provided during pregnancy if increased YFF values are detected.
Chromosome-damage; Humans; Reproductive-effects; Case-studies; Cancer; Ionizing-radiation;
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services