NIOSHTIC-2 Publications Search

Determination of Alkylation of Macromolecules in Mammals and Humans.

Authors
Golkar-Osterman-S
Source
NIOSH 1980 Oct:275-278
Link
NIOSHTIC No.
00105783
Abstract
A mathematical formula was developed to estimate the effective dose of a genotoxic compound for man. The formula predicts chemical alkylation of macromolecular nucleophilic sites based on the nature of the alkylating compound, and can be applied to red blood hemoglobin measurements in humans. The formula was successfully applied to data obtained from workers exposed to ethylene-oxide (75218) at an unspecified sterilization facility. The author notes that various factors can affect chemical alkylation of DNA, and that a correction factor should be used when estimating DNA alkylation from hemoglobin data.
Keywords
Analytical-models; Humans; Chromosome-damage; Toxic-effects; Hematology; Occupational-exposure;
CAS No.
75-21-8;
Publication Date
19801001
Document Type
Conference/Symposia Proceedings
Fiscal Year
1981
NIOSH Division
DSHEFS;
Source Name
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services
Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division