Determination of Alkylation of Macromolecules in Mammals and Humans.
NIOSH 1980 Oct:275-278
A mathematical formula was developed to estimate the effective dose of a genotoxic compound for man. The formula predicts chemical alkylation of macromolecular nucleophilic sites based on the nature of the alkylating compound, and can be applied to red blood hemoglobin measurements in humans. The formula was successfully applied to data obtained from workers exposed to ethylene-oxide (75218) at an unspecified sterilization facility. The author notes that various factors can affect chemical alkylation of DNA, and that a correction factor should be used when estimating DNA alkylation from hemoglobin data.
Analytical-models; Humans; Chromosome-damage; Toxic-effects; Hematology; Occupational-exposure;
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services