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In Vivo Teratogenicity Tests.
NIOSH 1980 Oct:219-225
In-vivo teratogenicity tests are described. Procedures used in animal testing are reviewed, including treatment periods, doses, and evaluation criteria. Complications arising due to toxic doses and pharmacokinetics of the test substance are evaluated. Extrapolation of the results of animal tests to man is discussed. The author concludes that in-vivo teratogenicity tests in animals have poor predictability for humans. Test improvement will require better design and interpretation, and selection of more appropriate animal species based on comparable metabolism to man.
In-vivo-study; Genetics; Animals; Research; Toxic-effects; Pharmacology;
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division