Standard In Vivo Tests For The Identification of Mutagens: Mitotic and Meiotic Effects.
NIOSH 1980 Oct:205-218
In-vivo tests for detecting chemical mutagens are reviewed. Criteria for in-vivo tests are listed. Test systems using micronuclei, bone marrow chromosomes, sister chromatid exchanges, and male and female germ cells are described. The authors conclude that the micronucleus test is rapid, simple, and can be performed by technicians. Metaphase studies are suitable for differentiating cytological effects. Sister chromatid exchange analysis is the most sensitive of all the tests, but the mechanism of induction is unknown. Several tests should be used to evaluate the mutagenic potential of a chemical.
In-vivo-study; Research; Chemical-kinetics; Standards; Genetics; Bone-marrow;
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services