Effects of in utero DES-exposure on human adults: testicular hypoplasia and abnormal semen in males; vaginal adenosis and ridges in females.
Gill-WB; Schumacher-GF; Bibbo-M
NIOSH 1980 Oct; :19-32
The effects of diethylstilbestrol (56531) (DES) on pregnant women and their male offspring were investigated. The study population included 346 DES treated women and 308 of their male offspring, and 319 placebo treated women and 307 of their male offspring first treated and examined in early 1950. Among the offspring, a significantly greater incidence of epididymal cysts and testicular hypoplasia was found in DES exposed males than in comparisons. No malignancies were found, and cytogenic analysis of urine did not reveal tumor cells. Functional abnormalities occurred primarily among the men with testicular hypotrophy. In the women, 15 percent of the DES exposed subjects had irregular menstrual cycles compared to 10 percent in the placebo exposed group, and duration on menstrual flow was shorter. DES women also had a greater incidence of vaginal adenosis and ridging, transformation zone, white epithelium, mosaic, and punctation. The DES treated women had fewer subsequent pregnancies and live births than the comparison women. The authors conclude that DES had a transplacental effect on male offspring, and may affect the subsequent fertility of exposed women.
Toxic-effects; Toxic-materials; Pregnancy; Reproductive-effects; Sex-factors; Drugs; Reproductive-system
Special Populations; Work Environment and Workforce;
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services