Industrial exposures to methyl-chloride (74873) are discussed. The toxic effects of methyl-chloride are reviewed along with analytical procedures for collection and analysis of methyl-chloride samples. Several workplaces that use methyl-chloride are described, together with various industrial applications of the chemical. Jobs requiring the use of methyl-chloride are identified, and current industrial hygiene and safety practices, including engineering controls, work practices, administrative controls, and biological and environmental sampling and control procedures are described. Chemical and physical data for methyl-chloride is presented. The results of detailed industrial hygiene surveys at four United States facilities where the chemical is used are included.