The major activities of NIOSH from January 1 through September 30, 1976 were reviewed. An automated storage and retrieval information system was instituted to assist NIOSH personnel in handling requests for occupational safety and health information. Health and safety guides were published providing management oriented information of OSHA standards and explanations of health and safety hazards. The series of Employee's Good Practices Manuals was developed. The Statistical Service branch prepared the Occupational Exposures Sampling Strategy Manual outlining a method for determining exposure. Many programs of engineering control systems were completed and new ones were initial in the plastics, resins and cutting fluids industries. Exhaust air follow up studies were conducted. New performance criteria were developed for respirators. A test system of pesticide cartridge evaluation was implemented. Respirator provisions were reviewed. Asbestos exposure hazard research was continued. Routine analytical support was provided and 27,629 analyses were performed. Approximately 20,000 instruments were calibrated. The report describes the activities of the Chemical Reference Laboratory, the Division of Criteria Documentation and Standards Development and various spheres of international cooperation and liaison activities.