The impact of low level cadmium feed on blood chemicals in male, Sprague-Dawley rats.
Rice DP; Murthy L; Shirley T; Menden E; Petering HG
Trace Subst Environ Health 1973 Jan; 7:305-311
The effect of low concentration dietary cadmium (7440439) on hemoglobin, hematocrit and serum amylase, zinc (7440666), copper (7440508), and ceruloplasmin was studied in male rats fed a semipurified diet. Drinking water was supplemented with 2.5, 5, or 10 parts per million (ppm) zinc, 0.25, 0.5 or 1ppm copper, and 0 or 17.2ppm cadmium. The cadmium groups received no cadmium for the first 41 days and thereafter received a cadmium supplementation. The duration of the experiment was 76 days. Tail blood samples were taken at intervals during the study and at sacrifice. Serum zinc varied with the amount of zinc in the drinking water. Ingestion of cadmium caused a depression of serum zinc in the animals fed 5 or 10ppm zinc, but not in those animals fed 2.5ppm zinc. Cadmium depressed serum copper concentrations, which varied with the concentration of copper in the diet. Serum ceruloplasmin concentrations were also depressed by cadmium. Serum amylase concentrations were not significantly affected by dietary zinc, copper, or cadmium. There were no changes in blood hematocrit or hemoglobin. Cadmium feeding had a similar effect on serum copper and ceruloplasmin concentrations in male and female rats.
NIOSH-Publication; NIOSH-Grant; Dietary-effects; Metallic-poisons; Biochemistry; Hematology; Laboratory-animals; Analytical-methods; Dose-response; Metabolism; Biological-effects
Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
7440-43-9; 7440-66-6; 7440-50-8
Trace Substances in Environmental Health
University of Cincinnati, Cincinnati, Ohio