HHE Determination, Report No. HHE-77-75-494, Dawes Laboratories, Chicago Heights, Illinois, June 1978.
NIOSH 1978 Jun:20 pages
Exposures to diethylstilbestrol (56531) (DES) were evaluated at Dawes Laboratories (SIC-2843) in Chicago Heights, on May 16 and 17, 1977. An evaluation request on behalf of approximately 15 to 25 individuals came from the Oil, Chemical and Atomic Workers Union Local 7-765 and the international office of the union. Workers were given complete medical examinations, and blood and urine DES concentrations were determined. Serum hormone concentrations also were measured. Total androgens and the free androgen index were decreased in workers with high DES exposure. Women commonly reported breast tenderness. Plasma DES concentrations ranged from less than 56 to 272 picograms per milliliter. DES concentrations in urine ranged from less than 21 to 286 picograms per milliliter. The author concludes that a health hazard exists at this company from overexposure to DES. Medical surveillance, careful record maintenance, engineering changes and the use of personal protective equipment are recommended.
NIOSH-Author; HHE-77-75-494; NIOSH-Health-Hazard-Evaluation; Hazardous-chemicals; Hazard-Confirmed; Region-5; Health-survey; Gynecological-disorders; Humans; Unions; Physiological-function; Carcinogens; Pharmaceutical-industry; Protective-equipment; Drug-manufacture;
Hazard Evaluation and Technical Assistance; Field Studies
NTIS Accession No.
Hazard Evaluation and Technical Assistance Branch, NIOSH, Cincinnati, Ohio, Report No. HHE-77-75-494, 20 pages, 5 references