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Health hazard evaluation determination report: HHE-77-75-494, Dawes Laboratories, Chicago Heights, Illinois.
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HHE 77-75-494, 1978 Jun; :1-20
Exposures to diethylstilbestrol (56531) (DES) were evaluated at Dawes Laboratories (SIC-2843) in Chicago Heights, on May 16 and 17, 1977. An evaluation request on behalf of approximately 15 to 25 individuals came from the Oil, Chemical and Atomic Workers Union Local 7-765 and the international office of the union. Workers were given complete medical examinations, and blood and urine DES concentrations were determined. Serum hormone concentrations also were measured. Total androgens and the free androgen index were decreased in workers with high DES exposure. Women commonly reported breast tenderness. Plasma DES concentrations ranged from less than 56 to 272 picograms per milliliter. DES concentrations in urine ranged from less than 21 to 286 picograms per milliliter. The author concludes that a health hazard exists at this company from overexposure to DES. Medical surveillance, careful record maintenance, engineering changes and the use of personal protective equipment are recommended.
NIOSH-Author; HHE-77-75-494; NIOSH-Health-Hazard-Evaluation; Hazardous-chemicals; Hazard-Confirmed; Region-5; Health-survey; Gynecological-disorders; Humans; Unions; Physiological-function; Carcinogens; Pharmaceutical-industry; Protective-equipment; Drug-manufacture; Author Keywords: Gynecomastia; Diethylstilbestrol; DES
Field Studies; Health Hazard Evaluation
NTIS Accession No.
National Institute for Occupational Safety and Health
Page last reviewed: December 11, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division