Teratologic Assessment of Butylene Oxide, Styrene Oxide and Methyl Bromide.
Sikov MR; Cannon WC; Carr DB; Miller RA; Mongtomery LF; Phelps DW
NIOSH 1980 May:84 pages
The general toxicology of butylene-oxide (106887) (Bo), styrene- oxide (96093) (So), and methyl-bromide (74839) (Mb) was investigated. Rats were exposed 7 hours a day for 5 days a week for 3 weeks, mated, and exposed for 19 days of gestation (dg). Pregnant rabbits were exposed 7 hours a day for 24 dg. Exposure chamber concentrations were monitored and ranged from 250 to 1,000; 100 to 300; and 20 to 70 parts per million (ppm) for Bo, So, and Mb, respectively. So concentrations were reduced to 15 to 50 ppm for rabbits. Bo and mb produced little toxic symptomology in rats; bo in both concentrations elevated rabbit mortality values; mb in the higher concentration tested produced severe neurotoxicity and 96 percent mortality. Bo produced minimal embryotoxic effects in rabbits when introduced at concentrations that were maternally toxic. Mb was not notably embryotoxic. An extensive mortality occurred with so exposures at 100 and 300 ppm for rats and rabbits, respectively. Lower concentrations were adopted for testing. A 50 ppm so inhalation exposure caused death in rabbits at a 79 percent rate and gestational exposure decreased fecundity in rats, increased resorptions in rabbits and decreased fetal weight and length in both animals. Embryonic ossification and other morphological defects were produced by so in rats and some soft tissue alteration was produced in rats by mb exposure.
NIOSH-Contract; Contract-210-78-0025; Toxicology; Laboratory-animals; Exposure-methods; Neurological-reactions; Reproductive-effects; Dose-response; Embryopathology; Teratogens;
106-88-7; 96-09-3; 74-83-9;
Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio, 84 pages, 29 references