Serum immunoglobulin levels in coal workers' pneumoconiosis.
Hahon-N; Morgan-WK; Petersen-M
Ann Occup Hyg 1980 Apr; 23(2):165-174
Serum immunoglobulin (Ig) levels were examined in 155 U.S. coal miners with pneumoconiosis. Seventy one males, (21 underground miners and 50 nonminers) with no evidence of pneumoconiosis served as a comparison group. The 155 miners were divided into 3 major divisions: those with Caplans Syndrome, those with progressive massive fibrosis, and those with simple pneumoconiosis. Radial immunodiffusion plates were used to quantitate serum concentrations of alpha-1-antitrypsin, complement component (C3) and IgA, IgM, IgG and IgD. Most differences noted in serum immunoglobulin levels and protein concentrations were between the 3 pneumoconiosis groups. Significantly higher serum immunoglobulin levels and protein concentrations were apparent in workers with pneumoconiosis when compared to those without the disease. Elevated levels of either serum immunoglobulins or proteins were not associated with bronchitic conditions among the workers. The authors conclude that inhalation of occupationally associated agents or dust may selectively stimulate components of the immunoglobulin systems.
NIOSH-Author; Measurement-methods; Respiratory-system-disorders; Humans; Analytical-methods; Analytical-instruments; Sample-preparation; Chemical-reactions; Immune-system; Occupational-exposure
W. K. C. Morgan, University Hospital, Department of Medicine, London, Ontario N6A 5A5, Canada
Annals of Occupational Hygiene