Criteria for a recommended standard... occupational exposure to o-tolidine.
Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-179, 1978 Aug; :1-77
A method is described for the sampling and analysis of o-tolidine (119937) , based on a method successfully used for benzidine (92875). Air is drawn through a two stage sampler consisting of a high efficiency fiber filter and a silica gel bed which collects o- tolidine and its salts. The filter and sorbent sections of the sampler are transferred to stoppered tubes and the o-tolidine is desorbed. A triethylamine/methyl-alcohol solution is injected into a high pressure liquid chromatograph. Peak readings are obtained and compared with a standard calibration curve. This method can detect 0.15 to 6.5 micrograms of benzidine per sample (3 to 130 micrograms per cubic meter for a 50 liter air sample) using 0.5 milliliters of desorbing solution and a 10 microliter injection into the liquid chromatograph. The authors suggest that the range of detection for o-tolidine should be similar to that for benzidine. The limit of detection for o-tolidine is predicted to be about 0.05 micrograms per sample.
NIOSH-Criteria-Document; Sampling-methods; Filters; Measurement-methods; Measurement-instrumentation; Industrial-organic-chemicals; Standards; Work-environment; Amines
Numbered Publication; Criteria Document
NTIS Accession No.
(NIOSH) 78-179; Contract-099-74-0031
National Institute for Occupational Safety and Health