n-Hexane-"free" hexane mixture fails to produce nervous system damage.
Egan-G; Spencer-P; Schaumburg-H; Murray-KJ; Bischoff-M; Scala-R
Neurotoxicology 1980 Feb; 1(3):515-524
The effects of chronic inhalation of a hexane (110543) mixture of 6 carbon (C-6) isomers free of n-hexane were examined. Male rats were exposed for 22 hours per day, 7 days per week for up to 6 months to 500 parts per million of the vapor. A positive control group was exposed to 100ppm of methyl-n-butyl-ketone (591786) (MnBK) and a negative control group was exposed to 500ppm of methyl-ethyl-ketone (78933) (MEK). Two animals from each test group were sacrificed after 2, 4, or 6 months of exposure for neuropathological examination. The animals exposed to the C-6 isomer mixture had no signs of neurotoxicity. The rats in the positive control group developed peripheral neuropathy after 4 months. Rats in the negative control group did not develop any signs of polyneuropathy. The authors conclude that hexane isomers that are free of n-hexane are not neurotoxic.
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Industrial-organic-chemicals; Neurotoxins; Neurological-reactions; Physiological-response; Neuropathology; Exposure-limits; Chemical-factory-workers; Laboratory-animals
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
110-54-3; 591-78-6; 78-93-3
Neurotoxic Disorders; Neurotoxic-effects
Yeshiva University, New York, New York