NIOSHTIC-2 Publications Search

n-Hexane-"free" hexane mixture fails to produce nervous system damage.

Egan G; Spencer P; Schaumburg H; Murray KJ; Bischoff M; Scala R

Neurotoxicology 1980 Feb; 1(3):515-524

http://www.neurotoxicology.com/journal.htm

00093699

The effects of chronic inhalation of a hexane (110543) mixture of 6 carbon (C-6) isomers free of n-hexane were examined. Male rats were exposed for 22 hours per day, 7 days per week for up to 6 months to 500 parts per million of the vapor. A positive control group was exposed to 100ppm of methyl-n-butyl-ketone (591786) (MnBK) and a negative control group was exposed to 500ppm of methyl-ethyl-ketone (78933) (MEK). Two animals from each test group were sacrificed after 2, 4, or 6 months of exposure for neuropathological examination. The animals exposed to the C-6 isomer mixture had no signs of neurotoxicity. The rats in the positive control group developed peripheral neuropathy after 4 months. Rats in the negative control group did not develop any signs of polyneuropathy. The authors conclude that hexane isomers that are free of n-hexane are not neurotoxic.

NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Industrial-organic-chemicals; Neurotoxins; Neurological-reactions; Physiological-response; Neuropathology; Exposure-limits; Chemical-factory-workers; Laboratory-animals

Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461

NRTXDN

110-54-3; 591-78-6; 78-93-3

19800201

Journal Article

807725

Grant

1980

Grant-Number-R01-OH-00535

3

0161-813X

Neurotoxic Disorders; Neurotoxic-effects

Neurotoxicology

NY

Yeshiva University, New York, New York