Carcinogenicity of beryllium: Review of the literature.
Environ Res 1980 Feb; 21(1):56-62
Experimental findings that demonstrate the carcinogenic aspects of beryllium (7440417) are reviewed. Beryllium compounds were the first nonradioactive chemicals that were found to cause osteogenic sarcomas and the first to produce lung cancer by inhalation in animals. Eleven different authors have published articles demonstrating that osteogenic sarcomas can be produced in rabbits by intravenous injection of beryllium compounds. Six other authors have published articles concluding that pulmonary neoplasms may be induced in rats by inhalation exposures to and intratracheal injections of beryllium compounds. Lung cancer has been produced in monkeys after inhalation exposure to beryllium. In view of these findings, the author concludes that beryllium is a carcinogen in laboratory animals, and that all beryllium compounds should be considered potential carcinogens.
NIOSH-Author; Metallic-poisons; Carcinogenesis; Respiratory-system-disorders; Laboratory-animals; Air-contamination; Exposure-methods; Tumorigenesis