Nonneoplastic effects of vinyl chloride in mouse lung.
Environ Res 1980 Feb; 21(1):235-253
Nonneoplastic effects in mouse lung were investigated by light and electron microscopy. Mouse lung tissue containing tumors caused by exposure to vinyl-chloride monomer (75014) was prepared for microscopy. Light microscopy showed proliferation and hypertrophy of the terminal bronchiolar cells and hypersecretion of the epithelial mucin in the goblet cells. Hyperplasia of alveolar epithelium and mobilization of alveolar macrophages were also observed. In electron microscope studies, Clara cells showed proliferation of the rough and smooth surfaced endoplasmic reticulum. Large and abnormally shaped mitochondria were seen and similar alterations were found in the ciliated cells. Submicroscopic changes in the pulmonary alveoli were also observed. The author suggests that the alveolar capillary endothelium and the septal cell probably are also affected by vinyl-chloride.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Laboratory-animals; Cellular-reactions; Lung-cancer; Dose-response; Plastic-materials-and-resins; Chemical-factory-workers; Histopathology
Community Medicine Mount Sinai School of Med Fifth Avenue & 100Th Street New York, N Y 10029
Mount Sinai School of Medicine, New York, New York