Chronic biological effects of methyl methacrylate vapor : III. Histopathology, blood chemistries, and hepatic and ciliary function in the rat.
Tansy-MF; Hohenleitner-FJ; White-DK; Oberly-R; Landin-WE; Kendall-FM
Environ Res 1980 Feb; 21(1):117-125
The effects of chronic exposure to methyl-methacrylate vapor (80626) (MMA) were studied. Rats were exposed for 56 hours over 7 days to 1,000 parts per million (ppm) of MMA, or to 116 and 400ppm MMA for up to 6 months. Blood and tissue analyses were performed. Mice were exposed intermittently for a total of 160 hours to 100 or 400ppm MMA. Twenty four hours after the final exposure, the mice were injected with 50 milligrams per kilogram of sodium pentobarbital. Sleep onset and duration times were recorded. Frogs were exposed for 61 hours over 7 days to 116 or 400ppm MMA. Mucosal ciliary function was tested. In the exposed rats, some blood chemicals were decreased, but overall blood chemistry did not differ from that of unexposed controls. Histopathological changes were observed in the lungs and tracheal mucosa following 1,000ppm exposure for 56 hours and 116ppm exposure for 6 months, respectively. In the mice, sleep induction time was shorter after 100ppm exposure, and sleep duration time was decreased with 400ppm treatment. Frogs exposed to 400ppm had reduced oropharyngeal transport efficiency. Liver damage occurred in rats and mice at all exposure concentrations. The authors suggest that the alterations of sleep induction and duration in the mice were related to the liver damage.
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Laboratory-animals; Air-contamination; Histology; Hematology; Gases; Dose-response; Physiology; Liver-function; Cellular-reactions
Physiology and Biophysics Temple University 3223 N Broad Street Philadelphia, PA 19140
Neurotoxic Disorders; Neurotoxic-effects
Temple University, Philadelphia, Pennsylvania