NIOSHTIC-2 Publications Search

Update on the toxicity of inhaled methyl methacrylate vapor.

Authors
Tansy MF; Kendall FM
Source
Drug Chem Toxicol 1979; 2(4):315-330
NIOSHTIC No.
00093168
Abstract
Information on the acute and chronic effects of methyl-methacrylate vapor (80626) (MMA) exposure is reviewed. Experimental results are included for studies on median lethal dose, subchronic toxicity, body weight and gross metabolic performance, blood chemistry, and cardiovascular response. Also reviewed are findings on central nervous system effects, histopathology, teratology, and gastrointestinal motility. The authors conclude that no data presently exists to indicate that routine occupational exposures to MMA are hazardous. Available information does suggest that low concentrations of the vapor can affect gastrointestinal motility. MMA is a powerful irritant and can induce cellular response. The authors recommend that the adequacy of the threshold limit value for MMA be evaluated on the basis of the cellular responses.
Keywords
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Gases; Air-contamination; Lethal-concentrations; Dose-response; Physiology; Cellular-reactions; Standards
Contact
Physiology and Biophysics Temple University 3223 N Broad Street Philadelphia, PA 19140
CODEN
DCTODJ
CAS No.
80-62-6
Publication Date
19790101
Document Type
Journal Article
Funding Amount
78696
Funding Type
Grant
Fiscal Year
1979
Identifying No.
Grant-Number-R01-OH-00518
Issue of Publication
4
ISSN
0148-0545
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Drug and Chemical Toxicology
State
PA
Performing Organization
Temple University, Philadelphia, Pennsylvania
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division