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Neurological dysfunction of the bladder in workers exposed to dimethylaminopropionitrile.
Kreiss K; Wegman DH; Niles CA; Siroky MB; Krane RJ; Feldman RG
JAMA J Am Med Assoc 1980 Feb; 243(8):741-745
An outbreak of bladder dysfunction among workers at a polyurethane (68400679) foam manufacturing factory in Massachusetts was investigated. Interviews were conducted with 208 employees about their job descriptions, use of protective clothing, and medical symptoms. Neurologic evaluations were performed on eight symptomatic workers. Symptoms were identified among 104 workers, most of whom worked at the production line. The workers reported hesitancy, the need to strain at urination, decreased urinary stream, and increased duration of urination. Some reported pain or discomfort. Symptoms or incidence were not sex related. Sexual difficulties also were reported. Sensory and sensorimotor neuropathy were found in seven of the eight affected workers that were tested. The onset of this epidemic was associated with the introduction of dimethylaminopropionitrile (1738256) (DMAPN) into the production process. When DMAPN was removed from the process, symptoms ceased abruptly, and no new outbreaks were reported. The authors conclude that DMAPN produces bladder dysfunction without producing frequent complaints of other organ or nerve dysfunction. They suggest that the mechanism of DMAPN action needs to be studied in animals.
NIOSH-Publication; NIOSH-Contract; Contract-210-78-0015; Plastic-materials; Chemical-factory-workers; Chemical-exposure; Sensory-perceptual-disorders; Neurological-disorders; Urogenital-system-disorders; Toxic-substances; Epidemiology; Recovery-time; Neurotoxicity
Dr Wegman, Occupational Health Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115
Issue of Publication
Journal of the American Medical Association
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division