Acrylonitrile pharmacodynamics and mutagenesis.
Environmental Science Laboratory, Mount Sinai School of Medicine of the City University of New York, New York, New York 1977 Jul; :1-8
The elimination routes and metabolism of acrylonitrile (107131) (AN) were investigated in the rat by studying kinetics in the blood following administration of 5 to 60 milligrams per kilogram doses. Blood samples were obtained at 5 to 10 minute intervals, and AN concentrations were measured using gas chromatography. AN concentrations in urine, feces, fat, and liver also were obtained where possible. Efforts to characterize possible metabolites were unsuccessful. AN had biphasic kinetic elimination from blood with half lives of approximately 10 to 50 minutes for the fast and slow rate constants, respectively. Both rates were dose dependent, and both were observed in liver tissue in-vitro. Induction with phenobarbital did not change the pharmacokinetic curve. Total AN measured in feces, urine, and tissues, represented only 3 to 30 percent of the administered dose, even at very short intervals following administration. AN did not appear to accumulate in the body, due to rapid, unchanged excretion in urine and feces and to rapid metabolism. The author concludes that the pharmacodynamics of AN are complex with at least two major metabolic pathways.
NIOSH-Grant; Neurotoxic-effects; Laboratory-animals; Malignant-neoplasms; Mutagenesis; Body-retention; Dose-response; Hematology; Chromatographic-analysis; Metabolism
Community Medicine Mount Sinai School of Medicine Fifth Avenue and 100Th Street New York, N Y 10029
Final Grant Report
NTIS Accession No.
Neurotoxic Disorders; Neurotoxic-effects
Environmental Science Laboratory, Mount Sinai School of Medicine of the City University of New York, New York, New York
Mount Sinai School of Medicine, New York, New York