Coal Workers' Pneumoconiosis: in vitro study of the chemical composition and particle size as causes of the toxic effects of coal.
Christian-RT; Nelson-JB; Cody-TE; Larson-E; Bingham-E
Environ Res 1979 Dec; 20(2):358-365
In-vitro cellular responses to leachates of Pennsylvania and Utah coal particles were compared in each particle size range to determine the toxic effects of leached substances. Leachates of respirable particles (1.5 microns or less) of the two coals caused significantly different responses: the leachates from Pennsylvania coal caused growth depression, while chemicals leached from Utah coal stimulated cell growth. The concentration of selected metals in the leachates of the two samples differed. The authors conclude that the difference between the cellular responses of the two coals is not dependent on particle size but rather on chemicals leached from those particles. Toxic substances leached from coal may be a factor in the etiology of Coal Worker's Pneumoconiosis.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Neurotoxic-effects; Coal-mining; Mine-workers; Coal-workers; In-vitro-studies; Toxic-effects; Respiratory-irritants; Airborne-particles; Physiological-response; Cellular-reactions; Growth-factors;
Environmental Health University of Cincinnati Eden & Bethesda Avenues Cincinnati, Ohio 45219
University of Cincinnati, Cincinnati, Ohio