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A comparative study of the effects of carbon monoxide and methylene chloride on human performance.
Putz-VR; Johnson-BL; Setzer-JV
J Environ Pathol Toxicol 1979 May/Jun; 2(5):97-112
Behavioral effects due to carbon monoxide (630080) (CO) or methylene chloride (75092) (MeC) inhalation were investigated. Six male and six nonpregnant female humans were exposed to CO or MeC concentrations designed to produce maximum 5 percent carboxyhemoglobin (COHb) concentrations during the fourth hour of exposure, and were assigned an eye and hand coordination task that was performed concurrently with peripheral brightness monitoring, and an auditory vigilance task. Subjects also were studied under no exposure as a control condition. Interactions between task difficulty levels, exposure time, and exposure conditions for response vectors were analyzed by multivariate analysis of variance. Finger prick blood samples were taken before and after exposure, and alveolar breath samples were collected every hour, during and after exposure. Both MeC and CO in the experimental concentrations had adverse behavioral effects which were similar in direction but varied in magnitude with certain tasks. The deteriorating effects of MeC and CO generally were evident only under difficult or demanding task conditions. The authors recommend that the effects of MeC and CO in concentrations sufficient to produce 5 percent COHb, either in combination or singly, be evaluated carefully for the arousal impact on workers.
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Issue of Publication
Journal of Environmental Pathology and Toxicology. Toxicological and Carcinogenic Health Hazards in the Workplace: proceedings of the First Annual NIOSH Scientific Symposium, Cincinnati, Ohio, April 1978
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division