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Toxicity evaluation for establishing IDLH values.
Price-NH; Yates-WG; Allen-SD; Waters-SW
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, TR 1518-005, NIOSH 1979 Apr; :1-248
Acute whole body inhalation toxicology from exposure to the industrial chemicals 2-aminoethanol (141435), 2- (diethylamino)ethanol (100378), diisopropylamine (108189), ortho- toluidine (95534), para-anisidine (104949), ortho-anisidine (90040), Aroclor 1254 (11097691), phosgene (75445), stibine (7803523), and diazomethane (334883) was tested in groups of 10 rats and 10 guinea pigs. Concentrations which produced no effect, a minimal effect, and an irreversible pathological effect were used. Experimental methodology included the design and operation of inhalation chambers, generation of the test compound atmospheres, atmospheric sampling and analysis, and animal procurement care, and pathology. Experimental data collected from the animal exposures is presented for each chemical used and for the differing exposure concentrations. Observations used to verify the impairment of ability of the test animals to escape, animal deaths, irreversible histopathological lesions, and the differences between control and test animal organ and body weight are presented. Data for each compound are summarized by results of chemical analyses, the type of effect, and the differences between test and control animal weight data.
NIOSH-Contract; Contract-210-77-0048; Laboratory-animals; Air-contamination; Measurement-instrumentation; Measurement-methods; Air-quality-measurement; Physiological-effects; Chemical-processing-industry; Safety-measures
141-43-5; 100-37-8; 108-18-9; 95-53-4; 104-94-9; 90-04-0; 11097-69-1; 75-44-5; 7803-52-3; 334-88-3
Final Contract Report
NTIS Accession No.
Contract-210-77-0048; TR 1518-005
National Institute for Occupational Safety and Health
University of Utah Research Institute
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division