Distal axonopathy: one common type of neurotoxic lesion.
Environ Health Perspect 1978 Oct; 26:97-105
The morphological aspects of neurotoxicity and the principles of testing for the detection of neurotoxic diseases such as distal axonopathies were evaluated. Methodology for establishing normative data for nerve fibers and cells were examined and a listing of toxic chemicals producing structural damage to the nervous system and pathological responses was compiled. Clinical response studies on chronic systemic intoxication of neurotoxic chemicals or drugs were reviewed. A new test for neurotoxicity that is based on the examination of selected areas of brain and nerve tissues was developed. Similarities between neurotoxic pathological expressions and naturally occurring neuropathies associated with human disease and the aging process also were considered.
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Laboratory-animals; Neurotoxins; Histopathology; Environmental-contamination; Clinical-studies; Morphology
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
Neurotoxic Disorders; Neurotoxic-effects
Environmental Health Perspectives
Yeshiva University, New York, New York