NIOSH 1979 Jun:108-110
Cellular transformations are discussed in relation to occupational carcinogenesis and experimental medicine. The use of animal models in cancer research, particularly in studies of inhalation cancer, is reviewed. The irritative effects of sulfite (14265453) in carcinoma production are noted, emphasizing the increased incidence of cancer among coke oven operators and workers exposed to roofing tar. Hexavalent-chromium (18540299) as calcium-chromate (13765190) is cited as the source of a 10 fold increase in the incidence of lung cancer in chromate workers. Ionizing radiation from radon and radon daughters is identified as the cause of lung cancer in uranium mine workers. A dose effect for ionizing radiation is shown to be experimentally validated. The effects of industrial byproducts on the general population are reconsidered. The author suggests that the microenvironment created by the individual for himself is a major characteristic in cancer induction.
NIOSH-Contract; Contract-210-78-0053; Carcinogenesis; Occupational-health; Epidemiology; Toxic-substances; Cell-alteration; Radiation-effects; Humans; Laboratory-animals;
14265-45-3; 18540-29-9; 13765-19-0;
Occupational Safety and Health Symposia 1978, Division of Technical Services, NIOSH, Cincinnati, Ohio