Reproductive Disorders of the Male/Female Worker: Short-Term Bioassays as Indicators for Potential Mutagens and Carcinogens - Current Status.
NIOSH 1979 Jun:31-36
Methods for detecting potential carcinogens and mutagens are reviewed. The advantage of using multitest evidence of mutagenicity is discussed. Inclusion of gene mutation, chromosomal abberation, and indicators of primary gene damage in test parameters is advised. Previous and ongoing research studies to evaluate mutagenicity test methods (particularly the Ames Test) are described. In-vitro transformation assay results are considered to have a closer relationship to man than other methods. The author concludes that in vitro assays are promising, but require further testing and validation, and that a combination of several assays and collaborative testing can provide meaningful mutagenetic information.
NIOSH-Contract; Contract-210-78-0053; Genetics; Bioassaying; Mutagenesis; Carcinogenesis; Analytical-methods; Toxicology; Research-laboratories; Reproductive-system-disorders;
Fertility and Pregnancy Abnormalities; Disease and Injury; Reproductive-system-disorders;
Occupational Safety and Health Symposia 1978, Division of Technical Services, NIOSH, Cincinnati, Ohio