Subclinical effects of chronic increased lead absorption - a prospective study. II. Results of baseline neurologic testing.
Baloh-RW; Spivey-GH; Brown-CP; Morgan-D; Campion-DS; Browdy-BL; Valentine-JL; Gonick-HC; Massey-FJ; Culver-r
J Occup Med 1979 Jul; 21(7):490-496
A standard neurologic examination, nerve conduction measurements, quantitative oculomotor function tests, and detailed audiologic studies were performed on 69 apparently healthy lead (7439921) workers with blood lead levels below 80 micrograms per 100 milligrams, and a matched control group from a nearby aluminum (7429905) processing facility to investigate subclinical and neurologic alterations and the progression or reversal of such alterations over time. Lead workers and controls were intermixed so that examiners were unaware of the status of any individual being tested. Although lead workers reported significantly more neurologic symptoms than the controls, relatively few differences were found. Decreased deep tendon reflexes were insignificantly more frequent in the lead workers than the controls (22 percent versus 11 percent). Peripheral neuropathy occurred with equal frequency in both groups, and the mean motor conduction, velocity, and latency measurements were not significantly different between groups. Of the six oculomotor function measurements, only the mean accuracy of saccadic eye movement was significantly different. The magnitude of high frequency hearing loss for each group was consistent with the noise levels to which they were exposed. The authors recommend further testing to validate their finding of impaired accuracy and saccadic eye movements in lead workers.
JOCMA7; NIOSH-Publication; NIOSH-Grant; Noise-induced-hearing-loss; Lead-absorption; Clinical-tests; Nervous-system-disorders; Chronic-toxicity; Medical-screening; Secondary-smelting; Nonferrous-metals; Metal-refining
Reed Neurological Research Ctr University of California Reed Neurological Res Center Los Angeles, Calif 90024
Journal of Occupational Medicine
University of California Los Angeles, Los Angeles, California