Immune Mechanisms in Byssinosis.
NIOSH 1978:142 pages
An immunological and physiological approach to the study of byssinosis which attempted to correlate in-vitro findings with results from animal exposure experiments is described. Although aqueous extracts of cotton bract and leaves were immunogenic for antibody synthesis in rabbits, no precipitating antibodies were detected in sera from cotton textile workers (SIC-2261) or from animals exposed to cardroom cotton dust for 15 weeks. Even though these plant part extracts contained true antigens, extracts of cotton stems and cardroom cotton dust were found to contain a polyphenolic tannin that interacted with and precipitated gamma globulin and beta lipoprotein in a pseudoimmune fashion from normal as well as byssinotic human sera. The potential for cardroom cotton dust to activate the complement system was examined using three different assays. Animals exposed over a period of 15 weeks to aerosols of cardroom cotton dust, responded with progressively larger decreases in PaO2, increases in PaCO2, and increases in the alveolar arterial oxygen gradient.
NIOSH-Author; Lung-disorders; Air-contamination; Worker-health; Industrial-processes; Physiology; Immunology;
Immunology Section, Laboratory Investigations Branch, NIOSH, Morgantown, West Virginia, Final Report, Project No. VKC-R22, 142 pages, 79 references