Behavioral and Neurological Evaluation of Workers Exposed to Perchloroethylene.
Tuttle-TC; Wood-GD; Grether-CB
NIOSH 1976 Feb:129 pages
A series of studies was undertaken to review the scientific literature regarding the known effects of exposure to perchloroethylene (127184) (PCE or tetrachloroethylene), to select a behavioral/neurological test battery for the detection of neurologic effects of exposure to PCE, to administer the test battery to workers exposed to levels below, at, and above the current Threshold Limit Value (TLV), and to investigate relationships between the behavioral/neurological measures, exposure indices, and medical data. PCE is a colorless, nonflammable liquid used as a solvent for oils, fats, resins, and cellulose-acetate. Relatively little has been published dealing with the long term effects of PCE exposure in humans. A preliminary conclusion of the studies is that PCE exposure at or below current TLV causes health problems for the workers. A tendency for the severity of neurological damage to vary with both level and duration of PCE exposure is reported. The relationships found between behavioral test battery scores and neurological data have important implications for industrial health screening programs. The primary objective associated with the use of behavioral measures would be to identify those workers who are suspected of having health impairment and who could be referred to a medical facility for an in-depth medical evaluation.
NIOSH-Contract; Contract-099-73-0035; Neurotoxins; Chlorinated-hydrocarbons; Occupational-health; Organic-solvents;
Westinghouse Behavioral Services Center, Columbia, Maryland, NIOSH Contract No. 099-73-0035, 129 pages, 11 references