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Effect of ehylene dibromide fumigated feed on animals.
Hebrew University, Faculty of Agriculture, Rehovot, Israel, Project No. A 10 AMS-4(a) 1966 Aug; :1-108
The effects of ethylene-dibromide (106934) (EDB) fumigation on animals and foods are reported. Oil seeds, cereal grain, animal feed, dried and fresh fruits and vegetables were treated with EDB in fumigation chambers of various sizes, using different concentrations (20 to 300g/m3), exposure times, and temperatures. The treated materials were then aired until no more free EDB was found. Quantitative analyses was by gas chromatographic analysis. Results showed that oily seeds absorbed the larger amounts of EDB which was enhanced by the presence of fat. The free EDB in the fumigated materials gradually disappeared leaving inorganic residues that were not injurious to animals. The air sampling showed that free EDB disappeared in the treated materials within a few days for fruits and vegetables, but remained for as long as 30 to 40 days in cereals and oily seeds. A simple field test utilizing a commercial halogen leak detector was developed and tested on cereal grain for a mixture of carbon-tetrachloride (56235), trichloroethylene (79016), carbon- disulfide (75150), and chloroform (67663). Residues of the fumigants were very small even after just 7 weeks of airing; however, traces of the fumigants were found after prolonged airing. Long term feeding trials of feed containing EDB on rats and farm animals including chickens, heifers, cows, ewes, young calves, and bulls indicated that laying hens were the most susceptible to EDB. Bulls treated with 2mg/kg/day EDB developed abnormal spermatozoa 2 weeks after administration, but rats and cockerels were not affected by 200ppm EDB in the feed. Acute exposure to single doses of 110 to 120mg/kg for rats and chicks and 80 to 90mg/kg for young calves were found to cause death. The main biochemical changes observed in acute EDB poisoning were an initial decrease of liver sulfhydryl groups and a later increase in liver sulfuryl groups. The main metabolite excreted was S-(beta-hydroxyethyl)mercapturic-acid. A detoxification mechanism is proposed which is similar to the metabolic pathway of ethylene-dichloride (107062) and ethylene- bromohydrin (540512).
NIOSH-Grant; Reproductive-system-disorders; Agricultural-chemicals; Analytical-methods; Biochemistry; Urine-chemistry; Halogenated-compounds; Food;
106-93-4; 56-23-5; 79-01-6; 75-15-0; 67-66-3; 107-06-2; 540-51-2
Final Grant Report
Hebrew University, Faculty of Agriculture, Rehovot, Israel, Project No. A 10 AMS-4(a)
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division