The 1977 update of the NIOSH Register reveals details on 64 cases of angiosarcoma of the liver in vinyl chloride (VC) (75014)/polyvinyl chloride (PVC) (PM9002864) workers. Since the original data on 26 cases of liver angiosarcoma, evidence continues to confirm this association. The date for 1977 are incomplete, but they suggest a gradual increase of reported cases of VC induced angiosarcoma. The increase in the number of cases is due to increased surveillance of VC/PVC workers and the growth of the industry since World War II. Recent trends indicate the age at diagnosis and latency period appear to be increased, which may be due to: 1) the initial cases having heavier exposures; 2) the initial cases being more biologically susceptible; or 3) random fluctuation in the incidences of liver angiosarcomas. Continued surveillance and reporting of liver angiosarcomas in VC/PVC workers is recommended to provide a base for further research.
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