Study of Enzyme Induction by Anesthetic Amounts Found in Ambient Air.
Berman ML; Bruce DL
National Institute for Occupational Safety and Health, Cincinnati, Ohio 1973 Mar:5 pages
The possibility of enzyme induction from the trace amounts of anesthetics found in operating room ambient anesthetic gases was studied in laboratory tests on randomly selected rats placed in exposure chambers into which air was either passed directly with no additions or with addition of nitrous-oxide (10024972) and halothane (151677) in final concentrations of 500 and 15ppm, respectively. The microsomal enzymes under study are responsible for the breakdown of barbiturates and the metabolism of physiologic steroid hormones, cortisol (50237), progesterone (57830) and testosterone (58220), which are related to the physiology of gestation and to an increased rate of spontaneous abortions among female operating room personnel. The investigations failed to show correlation between exposure to trace anesthetic concentrations and induction of rat liver microsomal enzyme activity. It is suggested that the inability to obtain statistically significant changes does not necessarily mean that no induction occurred, but that with this experimental design it was not measurable. Larger groups of test animals may be required.
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