Criteria for a recommended standard... occupational exposure to ethylene dibromide.
Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 77-221, 1977 Aug; :1-208
Chemical and toxicological properties, criteria, and recommended standards for ethylene-bromide (106934) (EDB) are reported. Data from human and experimental animal studies indicate that adverse effects from exposure to EDB include ocular, dermal, and respiratory irritation, and systemic effects on the liver, kidneys, spleen, cardiovascular, and central nervous systems. Dose response relationships and threshold levels have not been established; however, experimental data on animals strongly suggest that exposure to EDB can induce sterility, malformations, and hereditary damage. Carcinomas of the stomach have been produced in rats and mice administered EDB by direct intubation into the stomach. Epidemiologic evidence of adverse effects due to occupational exposure to EDB is not sufficient to identify a worker problem. However, higher death rates due to malignancies are apparent in employees having 6 or more years exposure to EDB. NIOSH recommends that the exposure limit of EDB be substantially lowered from the current federal standards of 20ppm for an 8 hour limit, 30ppm ceiling to a ceiling of 0.13ppm for any 15 minute sampling period. At this level an employee would have a maximum of about 686mg/kg for a 40 year working lifetime, which is substantially below the dose known to cause adverse effects in experimental animals. Medical surveillance should be provided for all employees working with EDB and records involving EDB exposure should be kept for 30 years after termination of employment. Recommendations are made for protective clothing and equipment to prevent dermal and ocular contact with liquid EDB. Further research is urged to provide a better scientific basis for the recommended health standards.
NIOSH-Criteria-Document; NIOSH-Contract; Contract-099-74-0031; Toxic-substances; Biochemical-responses; Pathologic-effects; Occupational-health; Hazards; Halogenated-compounds; Long-term-exposure; Low-level-exposure; Safety-measures; Safety-standards
Numbered Publication; Criteria Document
NTIS Accession No.
DHEW (NIOSH) Publication No. 77-221; Contract-099-74-0031
National Institute for Occupational Safety and Health