Results of the controlled exposure of human females to the vapor of methylene chloride.
Hake-CL; Stewart-RD; Forster-HV; Lebrun-AJ; Peterson-JE; Wu-A
NIOSH 1974 Mar; :1-22
The results of the controlled exposure of human females to the vapor of methylene-chloride (75092) are presented to supplement a previous comprehensive study of the effects of industrial exposure levels on male human subjects. The data obtained for nine healthy, volunteer human females, aged 20 to 41 years, concerned details of their general health and smoking habits, carboxyhemoglobin (COHb) levels, blood tests, EKG's, urinalyses, and behavioral performances during and after the experiment. None of the subjects were exposed to abnormal levels of carbon-monoxide (630080) (CO). Another report will cover the breath decay curves obtained during this study. The subjects completed subjective response forms at hourly intervals, noting any physiological reactions or symptoms. Neurological, behavioral and medical tests revealed no deleterious effects on the subjects. The determination of blood COHb saturation is considered to be a very accurate measure both of CO exposure and of the metabolization of methylene-chloride to CO; so it is not recommended for monitoring industrial exposures to methylene-chloride vapors where there is the possibility of low levels of CO in the atmosphere.
NIOSH-Contract; Contract-099-72-0084; Chlorinated-methanes; Hemoglobin-interactions; Oxides; Air-contaminants; Blood-chemistry; Environmental-hazards; Physiological-response; Medical-examinations; Human-exposure
Final Contract Report
NTIS Accession No.
National Institute for Occupational Safety and Health
The Medical College of Wisconsin, Department of Environmental Medicine