Electromotive interactions of metals in asbestos carcinogenicity.
University of Connecticut School of Medicine, Farmington, Connecticut 1975 Oct:44 pages
An investigation into the carcinogenicity of metallic dusts, manganese (7439965) (Mn), chromium (7440473) (Cr), aluminum (7429905) (Al), nickel-sulfide (1344496) (NiS), nickel-carbonyl (13463393), and iron carbonyl-(13463406) was performed. Intrarenal (i.r.) injection of nickel-subsulfate (7786814) (Ni3S2) was found to induce erythrocytosis in Fischer-rats. A single i.r. injection at 5 dosage levels from 0.6 to 10mg/rat caused erythrocytosis to develop reaching a maximum at 2 to 3 months. Blood erythrocyte counts returned to normal by 7 months. No significant changes occurred in leukocyte or platelet counts. Marked erythroid hyperplasia was present in bone marrow of rats that received i.r. Ni3S2, but not in controls or in rats that received i.m. Ni3S2. This study establishes the time response and dose response relationships for Ni3S2 induction of erythrocytosis in rats. Studies into the effects of Mn on tumorigenesis of Ni3S2 indicate that concurrent administration of Mn did not affect the local retention of Ni derived from Ni3S2. This study is consistent with the hypothesis that Mn may antagonize Ni (7440020) inhibition of RNA polymerase activity in rhabdomyocytes.
NIOSH-Contract; Contract-099-72-0024; Transition-metals; Nickel-compounds; Heavy-metals; Particulates; Carcinogenesis; Blood-disorders; Animal-models; Experimental-methods
7439-96-5; 7440-47-3; 7429-90-5; 1344-49-6; 13463-39-3; 13463-40-6; 7786-81-4; 7440-02-0
Final Contract Report
NTIS Accession No.
University of Connecticut School of Medicine, Farmington, Connecticut
University of Connecticut School of Medicine