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Chloro ethers -- occupational carcinogens, a summary of laboratory and epidemiology studies.
NIOSH 1975 Jun; :1-22
The relationship between chemical structure and carcinogenicity of a group of chloroethers is briefly reviewed, with data summarized from an extensive series of studies at the New York University Institute of Environmental Medicine on the chloroethers. Bis(chloromethyl)ether (542881) (BCME) and its monofunctional analog, chloromethyl-methyl-ether (107302) (CMME) produce tumors in subcutaneous tissue and skin in rodents. BCME is a highly potent vapor carcinogen for the rat lung and for the epithelial sheathing of the nasal nerve. Hydrochloric-acid (7647010) and formaldehyde (50000) can combine to form BCME. The extent of hazard from this combination is unknown. Epidemiologic studies of workers involved in chloroether manufacture have led to the identification of 34 cases of lung cancer in the United States and 13 in Europe. Active but less potent chloroethers have been identified in municipal drinking water in the United States.
NIOSH-Contract; Contract-210-75-0062; Ethers; Halogenated-hydrocarbons; Carcinogens; Toxic-substances; Carcinogenesis; Respiratory-irritants; Respiratory-system-disorders; Skin-neoplasms; Epidemiology; Chemical-manufacturing-industry; Chemical-industry-workers; Lung-neoplasms
542-88-1; 107-30-2; 7647-01-0; 50-00-0
Final Contract Report
NTIS Accession No.
NIOSH, Cincinnati, Ohio
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division