Tetrachloroethylene: development of a biologic standard for the industrial worker by breath analysis.
Stewart-RD; Hake-CL; Forster-HV; Lebrun-AJ; Wu-JE
NIOSH 1975 Jun; :1-173
The development of a biologic standard for exposure of industrial workers to tetrachloroethylene (127184) (PCE), based on breath analysis, was carried out in a comprehensive study using human volunteers. Particular emphasis was placed on: 1) the subject's health, including measurements of pulmonary, cardiovascular, and central nervous system functions during repeated, controlled exposures to PCE vapor; and 2) the relationship of exposure magnitude to PCE body burden, as demonstrated by the measurement of PCE or its metabolites in blood, urine and breath. A baseline is presented for additional studies which are needed to assure a healthful working environment wherever this chemical is utilized. The observations made and the data collected are provided, and a recommendation is presented for a biologic threshold limit value for tetrachloroethylene utilizing breath analysis decay curves. It is concluded that: 1) repeated daily exposure to PCE result in a tachyphylactic response regarding subjective feelings and odor detection, rendering these parameters unreliable as measures of exposure concentration; 2) considerable individual differences exist is response to PCE vapor exposure; 3) EEG analysis indicates preliminary signs of narcosis in most subjects exposed to 100ppm PCE for 7 1/2 hours a day; impairment of coordination may occur at 150ppm exposure for 7 1/2 hours; 4) CNS response is probably due to PCE; 5) postexposure breath analysis is an excellent method to estimate magnitude of body burden; and 6) physical exercise increases body burden.
NIOSH-Contract; Contract-099-72-0084; Chlorinated-hydrocarbons; Regulations; Physiological-response; Respiratory-functions; Analytical-methods; Air-contaminants; Blood-chemistry; Urine-chemistry; Physiological-function
Final Contract Report
NTIS Accession No.
National Institute for Occupational Safety and Health
The Medical College of Wisconsin, Department of Environmental Medicine