A study was conducted to develop a rapid and accurate test to determine the magnitude of industrial exposure to 1,1,1- trichloroethane (115208) (1,1,1-T) and to assess the physiological effects of vapor exposure. Twenty healthy adults of both sexes were exposed to known concentrations of 1,1,1-T in a controlled environment chamber. The exposure consisted of both steady, nonfluctuating vapor concentrations and widely fluctuating concentrations. Ten male subjects were exposed to concentrations of subjects were exposed to 0 and 350ppm for periods of 1, 3, or 7.5hr. Blood, urine and breath samples were collected. Neurological studies, pulmonary function tests, and cognitive tests were also performed. Subjects identically exposed for 5 consecutive days had very similar breath deacay curves. Post exposure breath analysis is a practical method to determine body burden of 1,1,1-T and so provides a biologic threshold limit measurement for workmen. Repetitive exposure to 350ppm 1,1,1-T produced responses in health subjects other than objections to the solvent's odor by the majority of female subjects.
NIOSH-Contract; Contract-099-72-0084; Analytical-methods; Respiratory-gas-analysis; Task-performance; Psychological-testing; Physiological-testing; Physiology; Dose-response; Body-retention; Organic-solvents; Aliphatic-hydrocarbons; Standards; Organic-vapors; Vapor-volume; Sampling; Behavioral-tests; Urinalysis; Sampling; Blood-tests