Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice.
Am Ind Hyg Assoc J 1977 Oct; 38(10):509-522
Mice were exposed to various concentrations of formaldehyde (50000) or acrolein (107028). Concentration response relationships were developed by measuring percent decreases in respiratory rate, indicating upper respiratory tract sensory irritation. Relationships are presented between the concentration associated with a 50% respiratory decrease and the threshold limit value (TLV). A summary of other animal inhalation studies is presented. The bases for the acrolein and formaldehyde TLVS are reviewed. Mice exposed for 4 days showed increasing sensitivity daily for both compounds. A reevaluation of the TLVS is suggested.
NIOSH-Grant; NIOSH-Publication; Irritants; Aldehydes; Herbicides; Dose-response; Pulmonary-function; Exposure-limits; Standards
Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
American Industrial Hygiene Association Journal
University of Pittsburgh, Pittsburgh, Pennsylvania